IMO, if you're going to use Emacs a lot, get used to the native command bindings and avoid CUA mode. Unfortunately, CUA mode conflicts with C-x and C-c which are the two major prefix keys. You couldn't pick two worse key bindings to conflict with if you tried. While CUA mode might be able to manage some of this, you'll always have other modes trying to bind things to one or other of those and virtually every piece of documentation will have to be reinterpreted. In short, don't make it hard on yourself; learn to use the native cut/copy/paste (C-w, M-w, C-y) keys and save yourself the hassle. That said, if you're on a Mac, you can use the Mac's native command key with Command-X, Command-C, and Command-V, without rebinding C-c/C-x. If you're on a PC platform (e.g., Windows or Linux), you're going to be stuck, though.